Briefly in reply and on the other end of the equation, one could also refer to the micro-cosmos.
(Sorry no picture in this instance)
I read somewhere that the number of protons in the currently known universe is around 10^49.
Be that as it may, if perchance just one atom, one proton, one electron or even one photon (and even of course smaller "particles" such as neutrinos), were somehow taken out of existence completely, just ONE of them, would this have any effect on the universe as a whole?
Of course with the micro-cosmos 10^49 protons is mind-boggling figure and a mind-boggling idea, but much greater numbers exist on even smaller scales.
Surely, if matter can neither be created or destroyed (1st Law of Thermodynamics), then each individual particle in the entire universe must have its own "purpose"...and I would suggest, is "numbered".
In short, eliminate from existence any one of these infinitesimally small particles, then the universe cannot exist.