The original sin, near as I can tell, occurred because Adam listened to his wife. :D
Seriously, "bone of my bone, flesh of my flesh" suggests to me Eve in a reflective sense represented to Adam his own body. Through her, "an help meet for him," he was to learn about himself. His error was to heed the counsel of his own bodily cravings as represented by Eve bringing him the fruit of which he did eat, rather than being obedient to God.
The knowledge of good and evil is a bodily concern. That which feels good or otherwise pleases the flesh, appetities, etc. is good. That which hurts or feels bad or otherwise offends the flesh is evil.
Adam by succumbing to the desires of the flesh (his other wife -- his virgin, according to Paul), effectively condemned the flesh, condemned the material to death and eventual corruption (cursed is the ground for thy sake).
But it wasn't all just about him. The consequences for Eve, whose lot was to represent the body (consider Paul's miscegynistic passages in this light) are similarly telling.
Difficult to swallow -- for both parties. But together, with God in the midst . . .
Just my two cents.