Ignorance (the old self) is The AntiChrist.
Those without the mind of Christ are ignorant of their sin and destined for destruction.
"But the natural man does not receive the things of the Spirit of God, for they are foolishness to him; nor can he know them, because they are spiritually discerned. But he who is spiritual judges all things, yet he himself is rightly judged by no one. For "who has known the mind of the Lord that he may instruct Him?" But we have the mind of Christ."
"He who is not with Me is against Me, and he who does not gather with Me scatters abroad."