The study of this and related substances is very vague--and there have been "discoveries" of miraculous substances over and over again. Some seem more social--and some seem more clinical. The only one I have no direct experience with is ayahuasca. I have knowledge and experience with the raw plants of cocaine, opium, marijuana, and LSD--and I've known users
IMO, so far, substance spirituality and religious spirituality without substances are totally different.