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"Gene-therapy" has been this miraculous promise for several decades now. A few amazingly effective examples have been produced, but over-all progress has been much slower than predicted. Complex systems are unpredictable! What a surprise... and now there might even be negative consequences from the tools used to carry out these miraculous therapies.

[www.scientificamerican.com]
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CRISPR-Edited Cells Linked to Cancer Risk in 2 Studies

Editing cells’ genomes with CRISPR-Cas9 might increase the risk that the altered cells, intended to treat disease, will trigger cancer, two studies published on Monday warn—a potential game-changer for the companies developing CRISPR-based therapies.

In the studies, published in Nature Medicine, scientists found that cells whose genomes are successfully edited by CRISPR-Cas9 have the potential to seed tumors inside a patient. That could make some CRISPR’d cells ticking time bombs, according to researchers from Sweden’s Karolinska Institute and, separately, Novartis.

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Subject Views Written By Posted
CRISPR meets the law of unintended consequences 1248 Nolondil 18-Jun-18 19:54
Re: CRISPR meets the law of unintended consequences 206 D-Archer 20-Jun-18 13:48
Re: CRISPR meets the law of unintended consequences 155 strontium3bood 01-Aug-18 14:07
Re: CRISPR meets the law of unintended consequences 159 Lost_In_Place 01-Aug-18 15:49
Re: CRISPR meets the law of unintended consequences 296 Lost_In_Place 04-Aug-18 02:58


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